NEWS AND VIEWS 27 November 2019 Drug resistance in malaria parasites is mediated by mutations in a transporter protein. The transporter’s structure reveals the molecular basis of how key mutations bring about resistance to different drugs. Leann Tilley & Leann Tilley is in the Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3010, Australia. Contact Search for this author in: Philip J. Rosenthal Philip J. Rosenthal is in the Department of Medicine, University of California, San Francisco, San Francisco, California 94143 USA. Contact Search for this author in: About half a million people, most of them children living in Africa, are killed each year by malaria 1 . Management of malaria, particularly that caused by the highly virulent protozoan parasite Plasmodium falciparum , is challenged by the emergence of resistance to antimalarial drugs 2 . Writing in Nature , Kim et al . 3 report the str