Lisinopril oral tablet: Side effects, dosage, interactions, and more - Medical News Today

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Lisinopril oral tablet can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking lisinopril oral tablet. These lists do not include all possible side effects.

For more information about the possible side effects of lisinopril oral tablet, talk with your doctor or pharmacist. They can give you tips on how to deal with any side effects that may be concerning or bothersome.

Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to notify the FDA about a side effect you've had with lisinopril oral tablet, you can do so through MedWatch.

Mild side effects

Mild side effects* of lisinopril oral tablet can include:

  • headache
  • dizziness
  • cough†
  • gastrointestinal (digestive) side effects†
  • chest pain‡

Most of these side effects may go away within a few days or a couple of weeks. But if they become more severe or do not go away, talk with your doctor or pharmacist.

* This is a partial list of mild side effects from lisinopril oral tablet. To learn about other mild side effects, talk with your doctor or pharmacist, or view lisinopril oral tablet's prescribing information.
† For more information about this side effect, see "Side effect details" below.
‡ This side effect was only reported in people taking lisinopril for heart failure.

Serious side effects

Serious side effects from lisinopril oral tablet aren't common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you're having a medical emergency.

Serious side effects and their symptoms can include:

  • Hypotension (low blood pressure). Symptoms can include:
    • trouble concentrating
  • Kidney problems, including acute (sudden) kidney failure. Symptoms can include:
    • swelling in your ankles or lower legs
    • shortness of breath
  • Liver damage. Symptoms can include:
    • jaundice (yellowing of your skin or the whites of your eyes)
    • pain in your upper right abdomen (belly)
    • unexplained weight loss
  • Angioedema (severe, sudden swelling that forms under your skin). Symptoms can include:
    • swelling that affects your arms, face, intestines, legs, lips, tongue, voice box, or vocal cords
    • trouble breathing
    • abdominal pain
  • Allergic reaction.*
  • Changes in potassium levels.*
  • Harm to a fetus or miscarriage, if used during pregnancy.†

* For more information about this side effect, see "Side effect details" below.
† Lisinopril has a boxed warning for this side effect. A boxed warning is the most serious warning from the FDA. For more information, see the "Lisinopril oral tablet and pregnancy" section below.

Side effect details

Here's some detail on certain side effects this drug may cause.

Cough

Cough may be a side effect of lisinopril for some people. This was one of the more common side effects reported by people taking the drug in clinical studies.

You may experience coughing within hours of taking your first dose of lisinopril oral tablet. It can also happen months after you start your treatment.

Although it's not common, some people have stopped taking angiotensin-converting enzyme (ACE) inhibitors such as lisinopril due to a cough that won't go away.

If you develop a cough while taking lisinopril, talk with your doctor. If the cough won't go away or is bothering you, your doctor may suggest another medication other than lisinopril to treat your condition.

Increased potassium levels

Some people taking lisinopril oral tablets may have increased potassium levels. This side effect is typically mild, but in rare cases, it can be serious.

People with kidney problems are more likely to have increased potassium levels with lisinopril. This is because having damaged kidneys makes it harder for your body to get rid of potassium.

You may also be more likely to have high potassium levels from taking lisinopril if you:

High potassium levels do not cause symptoms in most people. But in rare cases, you may have symptoms such as:

Your doctor will monitor your potassium levels using blood tests while you're taking lisinopril. But if you notice any of the symptoms listed above, talk with your doctor right away. This condition can be treated, and treating it sooner can help prevent it from becoming serious.

Gastrointestinal side effects

In rare cases, taking lisinopril can cause some gastrointestinal (digestive) side effects.

Gastrointestinal side effects reported by people taking lisinopril in clinical studies included:

  • constipation
  • diarrhea
  • flatulence (gas)

If you experience gastrointestinal side effects from lisinopril, talk with your doctor or pharmacist. Depending on the side effect, they may recommend treatment.

Gastrointestinal side effects such as constipation, diarrhea, and gas can sometimes be treated using over-the-counter (OTC) medications. But it's always best to talk with your doctor before you take any medication, including OTC drugs.

Allergic reaction and angioedema

As with most drugs, some people can have an allergic reaction after taking lisinopril oral tablet.

Symptoms of a mild allergic reaction can include:

  • skin rash
  • itchiness
  • flushing (temporary warmth, redness, or deepening of skin color)

A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:

  • swelling under your skin, typically in your eyelids, lips, hands, or feet
  • swelling of your tongue, mouth, or throat
  • trouble breathing

Taking lisinopril can also cause angioedema, which is severe, sudden swelling that forms under your skin. Symptoms can include:

  • swelling that affects your arms, face, intestines, legs, lips, tongue, voice box, or vocal cords
  • shortness of breath
  • abdominal (belly) pain

In some cases, you may be at higher risk for angioedema while taking lisinopril. For instance, your risk may be increased if you've had angioedema in the past that wasn't caused by taking an ACE inhibitor (such as lisinopril). You may also have a higher risk if you're Black. Use of ACE inhibitors has been linked with a higher rate of angioedema in Black people than in non-Black people.

Your doctor can tell you more about your risk of angioedema when taking lisinopril

Call your doctor right away if you have any kind of allergic reaction to lisinopril, as the reaction could become severe. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you're having a medical emergency.

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