Manual on meat inspection for developing countries

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necrotising enterocolitis :: Article Creator

1249 Non-Uniform Definitions Of Necrotising Enterocolitis As A Clinical Trial Outcome

Background: Outcomes in randomised controlled trials (RCTs) must be clearly defined so readers understand what has been measured, and meaningful synthesis of results can be conducted.

Necrotising enterocolitis (NEC) is a common, lifethreatening illness in preterm infants. It is therefore frequently measured as an outcome in RCTs evaluating interventions that affect the clinical condition of neonates.

The primary aim of this study was to examine whether NEC is clearly defined when it is reported in RCTs. The secondary aim was to compare diagnostic criteria between trials.

Methods: The Cochrane Central Register of Controlled Trials was searched for RCTs, published between 2000 and 2010, which reported NEC as a primary or secondary outcome and the definitions used were reviewed. We excluded conference abstracts and studies not published in English.

Main Results: Of 116 identified abstracts, 65 were included. In 18/65 (28%), no definition of NEC was provided. Of the remaining 47, 21 (46%) used a diagnostic definition of Bell's criteria stage two or greater. In the 26 studies that used other diagnostic criteria, 21 unique definitions of NEC were identified.

Conclusions: In RCTs, diagnostic criteria used to identify infants with NEC are often not defined. The several definitions of NEC which are used vary between studies. This impairs the interpretation and analysis of results of such studies. Given the current drive to standardise the measurement of outcomes in RCTs in paediatrics, there is a need for the clinical and research community to reach consensus around a valid, reliable definition of NEC.


Medications And Drugs For Treatment Of Necrotising Enterocolitis

Discover top medications for 'treating Necrotising Enterocolitis'? This page compiles essential information on generic and brand-name drugs specifically used for Necrotising Enterocolitis treatment.Here, you can explore dosages, prices, side effects, and administration recommendations to find a treatment that suits your needs. The FAQ drug section on some common drugs addresses questions, offering insights into prescribed Necrotising Enterocolitis medications and management strategies. Always check with your healthcare provider to confirm the suitability of any treatment option discussed here.

Medindia provides a very interesting Paediatric section for doctors

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