Vaccination
Host-Pathogen Protein Interactions In Tuberculosis: Key Insights And Implications
Delving into the complex network of host-pathogen interactions in tuberculosis, this topic unveils the crucial role of proteins in shaping the pathophysiology of the disease. Understanding these interactions equips researchers and clinicians with a profound understanding of tuberculosis dynamics and highlights potential targets for intervention. The intricate interplay between host and pathogen proteins significantly influences virulence and pathogenesis, offering insights into the mechanisms underlying TB infection. By exploring these protein interactions, the topic aims to advance knowledge and develop innovative strategies to combat tuberculosis. This research is pivotal in achieving the World Health Organization's goal of eradicating TB by 2035, providing a comprehensive view of the molecular and cellular interactions critical to TB pathogenesis and highlighting new avenues for therapeutic intervention.
This topic aims to thoroughly investigate the mechanistic roles of host and TB pathogen proteins in shaping the outcomes of Mycobacterium tuberculosis infections, with a particular focus on their influence on innate and adaptive immunity. By elucidating these roles, our goal is to significantly enhance the understanding of TB pathomechanisms, shedding light on the complex interplay between host defenses and M. Tb infection. This exploration will establish a robust foundation for the development of precise strategies aimed at mitigating tuberculosis. Furthermore, we seek to explore key regulatory pathways and protein factors governing host-pathogen interactions to harness this knowledge for the design and implementation of innovative approaches that effectively combat TB. Through this integrative approach, we anticipate not only uncovering the intricate mechanisms driving TB infection but also identifying new therapeutic targets and preventive measures crucial for addressing this pressing global health challenge.
We invite authors to contribute to a comprehensive synthesis of recent advancements in tuberculosis research. Significant progress has enriched our understanding of host-pathogen interactions, presenting an opportunity for a new publication to incorporate these latest findings and offer updated insights into TB virulence strategies and pathomechanisms. Authors are encouraged to spotlight emerging therapeutic targets among host and TB pathogen proteins, exploring their potential in innovative TB mitigation strategies, including host-directed and pathogen-host interface-based therapeutics. Additionally, the publication seeks to integrate multidisciplinary approaches, drawing from microbiology, immunology, molecular biology, and cell biology to provide a holistic perspective on TB pathophysiology and host-pathogen interactions. By synthesizing current knowledge and proposing practical strategies, this publication aims to advance efforts in combating TB and improving global health outcomes.
The topic editors declare that they have no conflicts of interest in relation to the editorship of this collection.
Keywords: Host-pathogen, interactions, tuberculosis, proteins, pathophysiology, virulence, pathogenesis, Mycobacterium, immunity, regulatory, pathways, infection, mechanisms, therapeutic targets.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Delving into the complex network of host-pathogen interactions in tuberculosis, this topic unveils the crucial role of proteins in shaping the pathophysiology of the disease. Understanding these interactions equips researchers and clinicians with a profound understanding of tuberculosis dynamics and highlights potential targets for intervention. The intricate interplay between host and pathogen proteins significantly influences virulence and pathogenesis, offering insights into the mechanisms underlying TB infection. By exploring these protein interactions, the topic aims to advance knowledge and develop innovative strategies to combat tuberculosis. This research is pivotal in achieving the World Health Organization's goal of eradicating TB by 2035, providing a comprehensive view of the molecular and cellular interactions critical to TB pathogenesis and highlighting new avenues for therapeutic intervention.This topic aims to thoroughly investigate the mechanistic roles of host and TB pathogen proteins in shaping the outcomes of Mycobacterium tuberculosis infections, with a particular focus on their influence on innate and adaptive immunity. By elucidating these roles, our goal is to significantly enhance the understanding of TB pathomechanisms, shedding light on the complex interplay between host defenses and M. Tb infection. This exploration will establish a robust foundation for the development of precise strategies aimed at mitigating tuberculosis. Furthermore, we seek to explore key regulatory pathways and protein factors governing host-pathogen interactions to harness this knowledge for the design and implementation of innovative approaches that effectively combat TB. Through this integrative approach, we anticipate not only uncovering the intricate mechanisms driving TB infection but also identifying new therapeutic targets and preventive measures crucial for addressing this pressing global health challenge.
We invite authors to contribute to a comprehensive synthesis of recent advancements in tuberculosis research. Significant progress has enriched our understanding of host-pathogen interactions, presenting an opportunity for a new publication to incorporate these latest findings and offer updated insights into TB virulence strategies and pathomechanisms. Authors are encouraged to spotlight emerging therapeutic targets among host and TB pathogen proteins, exploring their potential in innovative TB mitigation strategies, including host-directed and pathogen-host interface-based therapeutics. Additionally, the publication seeks to integrate multidisciplinary approaches, drawing from microbiology, immunology, molecular biology, and cell biology to provide a holistic perspective on TB pathophysiology and host-pathogen interactions. By synthesizing current knowledge and proposing practical strategies, this publication aims to advance efforts in combating TB and improving global health outcomes.
The topic editors declare that they have no conflicts of interest in relation to the editorship of this collection.
Keywords: Host-pathogen, interactions, tuberculosis, proteins, pathophysiology, virulence, pathogenesis, Mycobacterium, immunity, regulatory, pathways, infection, mechanisms, therapeutic targets.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
There Are Worlds Of Viruses In Our Bathroom
If you thought the rainforest was a hotspot of biodiversity, then you haven't looked at your toothbrush under a microscope. — dpa
Your toothbrushes and shower head are bustling with life, according to a new study published in the journal Frontiers in Microbiomes.
The researchers found that more than 600 different viruses are teeming around you during your morning routine.
"The number of viruses that we found is absolutely wild," says study leader Associate Professor Dr Erica Hartmann of Northwestern University in the United States.
"We found many viruses that we know very little about and many others that we have never seen before."
Microbiologists found that there was also minimal overlap between two samples, she adds.
"Each shower head and each toothbrush is like its own little island."
The good news is that the viruses are not dangerous for humans, but attack and multiply inside bacteria instead.
Such so-called bacteriophages have been the subject of increased research for some time now for the treatment of bacterial infections resistant to antibiotics.
The researchers think that the newly-discovered virus types could be a treasure trove for this.
Accordingly, many phages were found in the samples that specifically infect mycobacteria – the cause of diseases such as leprosy, tuberculosis and lung infections.
"It's amazing how much untapped biodiversity is all around us," says Assoc Prof Hartmann.
"And you don't even have to go far to find it; it's right under our noses."
For the study done in the US, the researchers asked people to send them used toothbrushes and swabs from their shower heads.
Previous analyses had already shown a great diversity of bacteria in the samples.
For the virus analysis, 34 samples from toothbrushes and 92 from shower heads were analysed.
"This project started as a curiosity," Assoc Prof Hartmann explains.
"We wanted to know what microbes are living in our homes."
Surfaces such as tables and walls are difficult for microbes to colonise because they prefer environments with water, she says.
"And where is there water?
"Inside our shower heads and on our toothbrushes."
The diversity of microbes in the bathroom is by no means a reason to go out and buy cleaning products with an antimicrobial effect, the research team also emphasises.
It is enough to change your toothbrush regularly.
There is also no need for special antimicrobial toothbrushes, because they are likely to lead to antibiotic-resistant bugs, Assoc Prof Hartmann notes.
When it comes to the shower head, cleaning it with soap, and if necessary, descaling agent is enough.
"Microbes are everywhere, and the vast majority of them will not make us sick," she says.
"The more you attack them with disinfectants, the more they are likely to develop resistance or become more difficult to treat." – dpa
Padres Star To Miss Beginning Of 2025 Season, Maybe Entire First Half
A season-ending injury has put the future of one San Diego Padres infielder in jeopardy.
Picking up Ha-Seong Kim's $8 million is a no-brainer as he is due a lucrative pay day in free agency, but his labrum surgery could complicate things.
General manager A.J. Preller said Monday that the procedure was completed earlier this month in Los Angeles by Dr. Neal ElAttrache and comes with a timeline that pushes the start of his throwing program toward the beginning of the 2025 season.
That means that Kim might not be ready to play until "May, June, July," Preller said.
"That's kind of the first question after the World Series that we've got to weigh," Preller said, " … whether we want to pick it up as a team, and he'll do the same on his front and then we'll get more information. After that, we'll keep gathering information on the injury standpoint, where that leaves him and us. But again, Ha-seong's very talented player. I think we felt that at the end of the year, not having him here. It definitely was a blow. And he's a guy who plays the game with a ton of energy. He's an intelligent baseball player. He defends the field really well. He can play all different spots, take a walk, he can hit a home run, he can steal a base. That's the way we evaluate him, and that's a really talented and valuable player. And again, like, I think, from our standpoint, we'd love to bring him back.
"I think we just got to kind of get into it and see where that leaves us."
Because Kim is going to miss the first half of the season, the Padres will have to figure out a temporary starting shortstop. It could be Xander Bogaerts, Jackson Merrill, or Fernando Tatis Jr.
Bogaerts is the favorite after signing two years ago to an 11-year, $280 million contract. However, his did struggle this season, hitting .264/.307/.381 and missing several weeks with a fractured shoulder.
"We'll talk to him about (Bogaerts' defensive position), but yeah, if we're going to be a playoff team next year, my guess is … Xander has an All-Star-type season, and I feel very confident he's capable of doing that," Preller said. "Part of it was the injury, but I think he's going to look at this year and make some adjustments to make sure that he comes back next year and he's back as one of the top players in the game."
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